NO SAFE! Titanium dioxide E171 no longer safe when used as food additive.

An expert panel of the European Food Safety Authority (EFSA) has concluded that they cannot exclude genotoxicity concerns after consumption of titanium dioxide particles.
Titanium dioxide is used as food colour (E171) to make food more visually appealing, to give colour or to restore the original appearance of food. It is frequently used in bakery wares, soups, broths, sauces, salads, savoury based sandwich spreads and processed nuts, but is also present in cosmetics, paints, and medicines.