The modification of Chile’s Supreme Decree 1358, which came into effect on August 13, 2024, establishes new regulations for the control of precursors and essential chemicals as stipulated by Law No 2000, which penalizes the illicit trafficking of narcotics and psychotropic substances. This regulatory change aims to improve regulation and supervision in the sector. Among the main adjustments is the expansion of the registration obligation in the RESUQ, which will affect a larger number of companies. Additional requirements are added, and the procedures for controlling and monitoring these substances are redefined.
Supreme Decree 1358 emerged in response to the need to regulate the control of precursors and essential chemicals in Chile, establishing a regulatory framework that provides tools for the prevention of abuse and the proper management of these substances. Below is the background and regulatory evolution of this decree.
Law No. 20.000, enacted in 2005, was a milestone in the regulation of drug control and substances that could be used for the manufacture of narcotics and psychotropics. This law laid the foundation for measures that allow the detection and control of chemical precursors, key elements in the fight against drug trafficking.
Since its enactment, this law has undergone various modifications and adjustments to adapt to emerging security and prevention needs. The comprehensive approach proposed by Law No. 20.000 aimed not only to control drug trafficking but also to regulate the industrial use of certain chemicals, which required authorities to implement more rigorous controls.
The modification of DS 1358 brings significant changes that affect companies managing precursors and essential chemicals. These adjustments are necessary to strengthen control and ensure safety in the handling of these substances. These measures are expected to contribute to greater efficiency in the supervision of companies and compliance with current regulations.

Chile’s Supreme Decree 1358, which establishes regulations for the control of precursors and essential chemicals, has been mandatory since August 13, 2024.
To ensure compliance with the new regulations, adjustments are implemented in control and monitoring procedures. These changes are essential to guarantee the effectiveness of the adopted measures and the safety in managing these substances.
The new control procedures will allow for more detailed monitoring of activities related to precursors and chemicals. These adjustments aim to increase the effectiveness in detecting irregularities and ensure better compliance with current regulations.
The new regulations of DS 1358 will bring various implications for companies, which must quickly adapt to meet the established requirements.
Adapting to the new regulations of DS 1358 is not only a legal requirement but also represents an opportunity for companies to move towards more responsible and efficient management of their operations.
The modification of DS 1358 will not only impact the national level but will also have repercussions on related regulations internationally. As Chile aligns with stricter standards, it is likely that a series of adaptations will be generated in other regulations involving the handling of chemicals and precursors.
The provisions of DS 1358 resemble regulations in other countries that seek to effectively control the use of chemicals. With the implementation of this modification, Chile can draw inspiration from successful international models, thus facilitating the creation of more robust policies. Regulations from countries like the United States, the European Union, and Australia can serve as references to adjust local standards and improve regulatory effectiveness.
It is essential for companies to prepare to meet international standards to compete in the global market without issues.



